MILWAUKEE — Jesus Aguilar, Travis Shaw and Eric Thames hit consecutive first-inning homers to spoil the debut of San Diego's Brett Kennedy and propel the Milwaukee Brewers to an 8-4 victory over the Padres on Wednesday night.
Kennedy, who was 10-0 in 16 starts at Triple-A El Paso before being called up Monday, was tagged for six runs on 11 hits in four innings.
Orlando Arcia and Christian Yelich also homered for Milwaukee, while Hunter Renfroe had a two-run shot for San Diego.
Jhoulys Chacin (11-4) allowed three runs on six hits in six innings to win for the fifth time in six decisions.
Kennedy (0-1) retired Yelich on a groundout to open the game, but the next seven hitters reached. Lorenzo Cain singled to right and advanced to third on Mike Moustakas' opposite-field bloop single down the left-field line.
Aguilar then drove a 3-2 pitch the other way over the right-field wall for his team-leading 28th home run. Shaw followed with his 23rd homer and Thames added his 16th to put the Brewers up 5-0.
Kennedy, who had allowed just six homers in 89 1/3 innings in the Pacific Coast League, then allowed singles to Erik Kratz and Orlando Arcia before retiring the next two hitters.
The Brewers made it 6-0 in the second on singles by Cain and Aguilar and Shaw's sacrifice fly.
San Diego pushed across run in the fifth. Austin Hedges singled and Freddy Galvis walked. Chacin then snagged Franmil Reyes' scorching liner and doubled Galvis off first. Hedges came around on Cory Spangenberg's single under the glove of first baseman Aguilar.
Arcia answered in the bottom half with his third homer, a two-out solo shot to center.
Renfroe's two-run homer in the sixth, his 11th, cut the lead to 7-3, but Yelich countered with his 18th homer to open the bottom half.
Padres: LHP Robbi Erlin (2-3, 3.34) will make his fourth start of the season, along with 27 relief appearances. He made one start in May and another in June, before starting Aug. 2 against the Cubs, allowing one run in five innings for his ninth career victory as a starter.
Brewers: RHP Junior Guerra (6-7, 3.42) has not won in four starts since July 8. He has allowed 15 earned runs in 22 innings over that span. Guerra has a 2.55 ERA in 13 starts at Miller Park, compared with 4.97 on the road.