– Carsen Edwards said he was getting tired of answering questions about his shooting slump.

The Purdue star had all the answers Saturday night. He scored a career-high 42 points as the Boilermakers knocked reigning national champion Villanova out of the NCAA tournament in an 87-61 rout.

Matt Haarms added 18 points and nine rebounds for the third-seeded Boilermakers (25-9), who advanced to their third Sweet 16 in a row. Ryan Cline added 12 points, all on three-pointers.

Eric Paschall had 19 points for Villanova (26-10), which saw its quest for a third national title in four seasons end during the tournament's first weekend. Fellow senior Phil Booth scored 15 points, putting him over 1,500 for his career.

Edwards has battled a sore back and coming into the tournament had shot only 32 percent from the field in his previous 11 games.

Against Old Dominion in the first round he wasn't much better, scoring 26 points but on 7-for-23 shooting, including 4-for-12 from behind the arc.

He found the bottom of the net early and often Saturday, making 12 of 21 shots and nine three-pointers on 16 attempts.

"I wouldn't say I knew I had a career night until the game was over," Edwards said. "I was just so focused on trying to get the win, especially in games like this where you value every possession."

Purdue shot 54 percent while holding Villanova to 20 baskets on 58 shots (34 percent).

It was the worst NCAA tournament loss in the Wildcats' storied history and the largest blowout of a defending champion since 1990, when Loyola-Marymount beat Michigan 149-115 in the second round.

"This game is a humbling game," said Villanova coach Jay Wright, whose team has alternated second-round exits and NCAA championships for five years in a row. "We didn't get up on Edwards early, didn't get up on Cline early and when great shooters get hot, you're in trouble."