Minnesota Vikings center Pat Elflein snaps the ball during the first half of an NFL football game against the Detroit Lions, Thursday, Nov. 23, 2017, in Detroit. (AP Photo/Duane Burleson)As the Vikings try to handle the Carolina Panthers' fourth-ranked run defense on Sunday, they'll have to do so without rookie center Pat Elflein.

Elflein, who was listed as questionable for the game with a shoulder injury that limited him in practice all week, won't play for the Vikings on Sunday in Charlotte. He'll join tackle Mike Remmers among the Vikings' offensive line starters to miss Sunday's game, while Nick Easton starts at center.

The loss of the rookie, who's put together an impressive season through 12 games, could be a blow for the Vikings as they try to establish their run game on Sunday, but they did use Easton as their center for much of training camp, and they have a capable backup in Jeremiah Sirles, who'll start at left guard.

Here is the Vikings' full list of inactives for Sunday:

QB Kyle Sloter

WR Stacey Coley

Associated Press, Star Tribune

C Pat Elflein

T Mike Remmers

TE David Morgan

DE Tashawn Bower

DT Jaleel Johnson