By besting his previous career high by three, Johan Santana broke the Twins record for strikeouts in a single game Sunday. The top five strikeout performances in team history:
| K | Pitcher | Opponent | Date | Result |
| 17 | Johan Santana | vs. Texas | Aug. 19, 2007 | W 1-0 |
| 15 | Bert Blyleven | vs. Oakland | Aug. 1, 1986 | W 10-1 |
| 15 | Jerry Koosman | vs. Kansas City | June 23, 1980 | W 4-1 |
| 15 | Joe Decker | at Chicago White Sox | June 26, 1973 | W 4-0 |
| 15 | Camilo Pascual | at Los Angeles Angels | July 19, 1961 | W 6-0 |
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