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Hosszu plans to scratch from this event to focus on racing China's Ye Shiwen in the 200 IM final.
Franklin won the 100 back in 58.33 at the London Games.
Can she approach the world record of 58.12 set by Britain's Gemma Spofforth in 2009?
"I haven't even thought about it," Franklin said. "I'm just going to go out there and swim and have fun. When you focus too much on a number you kind of lose what swimming is all about. So I'm just going to go out there and see what I can do."
Ledecky, however, is clearly eyeing Kate Ziegler's world record of 15:42.54 in the 1,500 — a non-Olympic event.
"I definitely have a lot left in the tank," Ledecky said. "I just wanted to win my heat and swim a controlled race."
Ledecky won the 400 free in a dominating performance Sunday.
"I just carried the energy and excitement from last night into this morning and recovered well," she said.
|Philadelphia - A. Harang||12:05 PM|
|Washington - J. Zimmermann|
|Atlanta - A. Wood||12:07 PM|
|Toronto - R. Dickey|
|Chicago WSox - C. Sale||12:08 PM|
|Detroit - A. Sanchez|
|Cleveland - D. Salazar||1:10 PM|
|Minnesota - P. Hughes|
|Cincinnati - H. Bailey||1:15 PM|
|St. Louis - C. Martinez|
|San Diego - T. Ross||1:20 PM|
|Chicago Cubs - K. Hendricks|
|Baltimore - C. Tillman||3:05 PM|
|Boston - C. Buchholz|
|Milwaukee - K. Lohse||6:05 PM|
|Pittsburgh - J. Locke|
|Miami - M. Latos||6:10 PM|
|NY Mets - J. deGrom|
|LA Angels - C. Wilson||6:10 PM|
|Houston - D. Keuchel|
|NY Yankees - M. Tanaka||6:10 PM|
|Tampa Bay - J. Odorizzi|
|Oakland - J. Hahn||6:10 PM|
|Kansas City - Y. Ventura|
|Arizona - R. De La Rosa||8:05 PM|
|San Francisco - C. Heston|
|Colorado - J. Lyles||8:10 PM|
|Los Angeles - Z. Greinke|
|Texas - C. Lewis||8:10 PM|
|Seattle - F. Hernandez|
|New Orleans||2:30 PM|
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|Toronto FC||7:30 PM|
|Vancouver FC||8:30 PM|
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|Sporting Kansas City||9:30 PM|