"I would say (it's a) very black day," Cilic said of the spate of injury withdrawals. "The other days, other weeks, there were no pullouts. Everything just happened today."
If that wasn't enough, the tournament lost five former No. 1 players Wednesday: Sharapova, Azarenka, Caroline Wozniacki and Ana Ivanovic among the women, and Lleyton Hewitt among the men.
With Azarenka and Sharapova gone, the prospect of Serena Williams lifting the women's trophy for a sixth time look even stronger. Williams, who is riding a 32-match winning streak, had already been considered the overwhelming title favorite.
There were a few moments of normality on this crazy day at the All England Club.
Second-seeded Andy Murray advanced easily to the third round with a 6-3, 6-3, 7-5 victory over Yen-hsun Lu of Taiwan on Court 1.
Murray served 11 aces and had 41 winners against only 14 unforced errors for his second consecutive straight-set win. The U.S. Open champion remains on course in his bid to become the first British man to win Wimbledon in 77 years.
The 20-year-old Larcher de Brito played the match of her life against Sharapova on Court 2 to reach the third round of a Grand Slam for only the second time.
Larcher de Brito held her nerve in the final 10-minute, 18-point game to serve out the match. She saved two break points and finally converted on her fifth match point when Sharapova hit a forehand into the net.
"I can't believe it," Larcher de Brito said. "I just tried to stay calm. I just played so well. I just hung in there. In the last couple of points or games I just gave it my all and went for it."
Sharapova tumbled several times on the grass. Trailing 3-2 in the second set, her right leg gave way behind the baseline and she did the splits.
Sharapova took a medical timeout and complained to the umpire about the grass conditions. She said later she believed she strained a hip muscle.
"I don't think I've ever fallen three times in a match before in my career, so that was a little strange," Sharapova said. "But that's certainly not an excuse.
"I think today I've seen a lot of players fall and take a few hits and a few injuries. So I think that's just part of the game, part of what we have to deal with."
Azarenka, the two-time Australian Open champion, pulled out after hurting her right knee in her opening-round win against Maria Joao Koehler. She withdrew minutes before her second-round match against Flavia Pennetta.
Azarenka reached the semifinals at Wimbledon the last two years and had been seeded to face Williams in the final.
It's only the second time in the Open era that a women's player seeded in the top 2 has conceded a match by walkover at any Grand Slam. The last time it happened was in 1974 at the French Open when second-seeded Nancy Richey pulled out before a match.
In her match against Koehler, Azarenka did the splits near the baseline, then crumpled to the grass, clutching her right knee and sobbing. She recovered after a medical timeout to win.
Azarenka said on Wednesday that medical tests showed she had a bone bruise rather than a tear but was unable to recover in time.