KANSAS CITY, MO. — No. 2 Kansas had taken care of the ball as well as any team in the country this season, never beating itself.

In the biggest game in school history, crucial mistakes and missed opportunities ended the Jayhawks' unbeaten season.

No. 3 Missouri beat Kansas 36-28 Saturday night, dashing the Jayhawks' national championship hopes.

Todd Reesing avoided an interception for a Big 12 record 213 passes, then was picked off twice by Missouri (11-1, 8-1), which converted both into touchdowns.

The Jayhawks' only penalty of the game kept alive an early Missouri scoring drive, and kicker Scott Webb had a rough game with two missed field-goal attempts.

Webb also drilled an onside kick right to Missouri's Tommy Saunders at the Kansas 40 with 2:04 to go and the lead cut to six points.

The Jayhawks regained possession with just 17 seconds remaining and Reesing was tackled for a safety.

That was enough to tilt the balance in favor of the toughest team Kansas (11-1, 7-1) has faced all season, sending the Tigers to San Antonio on Saturday to play Oklahoma for the Big 12 title.

"Here we go, San Antonio," Missouri quarterback Chase Daniel told ABC-TV after the game. "This is part of our journey.

"We played our hearts out, and so did they."

Daniel was 40-for-49 passsing for 361 yards and three touchdowns, with no interceptions.

Kansas trailed 14-0 after going scoreless in the first half for the second time of the season, and 21-0 after Castine Bridges' interception and 41-yard return of an offline Reesing pass set up an early touchdown in the third quarter. After that, the best the Jayhawks could do was trade scores.

Dexton Fields' 10-yard catch with 8:28 to go cut the gap to 31-21, adding pain to Webb's missed field goal attempts of 33 and 45 yards in the second quarter. Webb ended the season missing seven of his past 12 field-goal attempts.

Reesing broke the Big 12 record of 205 consecutive passes without an interception on his first throw of the game, and extended it to 213 before William Moore picked off an underthrown ball at the 2 with 14:35 left in the half. That started a drive that ended with Daniel's 11-yard touchdown pass to Danario Alexander.