Ian Cole scored his first goal of the season in his 500th NHL game, backup goalie Pavel Francouz stopped all 16 shots he faced in relief and the Colorado Avalanche beat the Bruins 4-1 on Saturday night in Boston for its season-high sixth straight win.
Andre Burakovsky, Valeri Nichushkin and Gabriel Landeskog also scored for Colorado, which has won 11 of its past 14 games. The Avalanche posted its 11th win in its past 12 games in Boston, with their only loss in the stretch coming in the last trip on Feb. 10 last season.
Francouz replaced starter Phillip Grubauer late in the first period. Grubauer left with an apparent injury after giving up a goal on four shots.
Chris Wagner scored for Boston, which lost its second straight and first in regulation at home this season after going 12-0-5. The Bruins were the NHL's last team without a regulation loss on home ice.
The Bruins became the first Boston-area professional team to lose at home since the Red Sox lost to the Baltimore Orioles on Sept. 28. The Patriots are 5-0 at home this season, and the Celtics improved to 9-0 on Friday. (The Revolution won its last home game on Sept. 29, and the Pride of the National Women's Hockey League is 9-0 at home.)
Lightning 7, Sharks 1: Andrei Vasilevskiy made 37 saves, and Steven Stamkos had two power-play goals and an assist as Tampa Bay won at home.
Tampa Bay also got two goals from Tyler Johnson.
After tying Stan Mikita, Joe Mullen and Darryl Sittler for 49th place on the NHL power-play list on his first goal with 27 seconds to go in the second, Stamkos then tied Glenn Anderson for 48th with his 151st career man-advantage goal in the third.
Panthers 4, Blue Jackets 1: Sergei Bobrovsky made 33 saves against his former team and Josh Brown scored the winning goal in Florida's victory at home over Columbus.
Canucks 6, Sabres 5: J.T. Miller scored a power-play goal 3:21 into overtime to lift host Vancouver.
Buffalo's Marcus Johansson scored with 59 seconds left and his team's goalie pulled in the third period to tie it at 5, but Miller scored his 13th of the season off a pass from rookie defenseman Quinn Hughes in overtime.