Harry and Louise are returning to television screens this weekend to talk about overhauling health care. But they've switched sides.

The original insurance industry TV ads, featuring the fictional couple (portrayed by actors Louise Caire Clark and Harry Johnson), played a big role in derailing President Bill Clinton's effort to revamp the medical system in the 1990s.

Now, the real-life couple will appear in a $4 million TV campaign supporting a reshaping of health care, sponsored by Families USA, which champions affordable health care for families, and the Pharmaceutical Research and Manufacturers of America. The two groups, often at odds, have joined forces to support some general principles behind revamping health care.

Clark, 59, and Johnson, 66, both Democrats, said they supported Clinton but not his health plan. But this time, Clark said, she believes President Obama can overhaul the system.

ASSOCIATED PRESS