An emerging field brings together doctors, mathematicians, programmers and other professionals in an effort to grasp the complexities of the human body.
It’s hard to see the future of medicine through the scabs, blisters and scars that torment 7-year-old Charlie Knuth as he makes his way haltingly to a checkup at the U of M Amplatz Children’s Hospital.
But the boy from Appleton, Wis., is helping doctors perfect a pioneering intervention called gene editing, a procedure that could lend hope to thousands of people suffering from hundreds of diseases — including epidermolysis bullosa, the disorder that causes Charlie’s skin to shear off and his eyes to blister.
Charlie’s case also illustrates the power of an emerging field called “biomedical and health care informatics” that’s beginning to revolutionize every aspect of medicine, from laboratory research to clinical treatments.
The doctors and Ph.D.s helping Charlie — a team that includes scientists at the U, in Massachusetts and in Germany — couldn’t have done their work without mining a massive genomic database that enabled them to interpret millions of bits of data in the boy’s DNA, according to Dr. Jakub Tolar, director of the U’s Stem Cell Institute.
That, in turn, allowed them to cut out a single, defective gene and splice in a correction without damaging side effects.
The procedure, which they described in a recent issue of the journal Molecular Therapy, is part of a larger movement that has medical professionals collaborating with physicists, mathematicians, statisticians, social scientists and computer engineers in an effort to create and mine “Big Data” centers. Much as Google, Facebook and Amazon mine massive amounts of data to discern consumer preferences, these researchers are sifting huge quantities of medical data to diagnose, understand and cure diseases.
The U, Mayo Clinic and several Minnesota businesses are well-positioned to take advantage of the trend. Five years ago, the U launched a special graduate program in Biomedical Informatics and Computational Biology (BICB). Partners include its Twin Cities and Rochester campuses, the Hormel Institute, Mayo, IBM, the National Marrow Donor Program and a brain research center at the Minneapolis Veterans Medical Center. And three years ago the U received a $5.1 million federal grant specifically to train health professionals in informatics.
Turning data into wisdom
Biomedical informatics starts from a simple premise: The human body represents a databank of stunning depth and complexity.
By 2015, the average hospital will have nearly 450 terabytes of patient data — most of it in the form of large, complex images from CT scans, MRIs and similar imaging techniques, according to researchers at IBM and Wayne State University.
Beyond that are myriad other digital streams that could be tapped, such as Facebook and Twitter posts, which have proved useful in epidemiological studies, or monitoring devices such as Microsoft Kinect, which is being studied to understand movement disorders such as Parkinson’s disease.
And the stock of digital data will roughly double in volume every two years, according to a recent study sponsored by EMC Corp., a Massachusetts data storage and computing company.
Yet only a small fraction of existing data has been analyzed, which creates a huge job growth opportunity.
“We go from data to information, to knowledge to wisdom,” Tolar said. “And unless we have a very systematic way of looking at the data, we will not only lose a lot of the information, but also, we will do harm, in my opinion.”
The Obama administration put up $200 million last year for an initiative to improve medical care and cut costs by mining the growing stores of health data. At the National Institutes of Health (NIH), a program called Big Data to Knowledge (BD2K), underwrites projects such as mapping every neuron connection in the brain and large-scale genome sequencing of cancerous tumors.
“The goal is to develop new tools to analyze, organize and standardize all this data, so that it is easy for scientists to share and access,” NIH director Dr. Francis Collins explained.
Connie Delaney, dean of the U’s School of Nursing in Minneapolis and acting director of the Institute for Health Informatics, says the application of data mining to health care represents “a fundamental paradigm shift” that affects every scientific discipline and requires unprecedented collaboration to tap the breadth of skills required.