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The new face of diabetes

Last update: November 11, 2000 - 10:00 PM

When Jodi Dianchrist, 35, and her husband decided to buy more life insurance four years ago, she figured that her husband was the one who should worry about passing the physical exam required by State Farm.

Both were in good health, but Jodi exercised and tried to watch her diet, although she needed to lose some weight. Nor was the Inver Grove Heights woman's family tree clouded by cancer, heart disease or other serious health conditions. Her relatively young age also was a plus.

So when her physician told her that she had Type II diabetes, the adult-onset form of the disease, Dianchrist was shocked:

"I kept thinking: Me? I have diabetes? And then I thought: You can't tell me this, because I hate needles! I can't have diabetes!"

Not long ago, a diagnosis of Type II diabetes in a young adult was a rarity. The juvenile form of this disease -- a malfunction of the immune system -- usually begins in childhood, while Type II has historically been a condition of the elderly. In fact, many of today's physicians were taught that age was a critical component of diagnosis: Type II happened mostly to those 60 and older, while anything in those age 40 and under was Type I.

That's changing rapidly, however, and experts are sounding the alarm about a new and serious public health threat.

In August, the federal Centers for Disease Control and Prevention reported that the incidence of diabetes grew by 33 percent in the United States from 1990 to 1998, with an especially sharp increase among young adults. The number of diagnoses among people in their 30s rose 76 percent, while diabetes among those in their 40s rose 40 percent.

Most of the new cases involved Type II diabetes.

Physicians also report a growing number of teens and people in their 20s with this disease, and sharp increases among certain ethnic groups, such as American Indians, blacks and Hispanics.

"What we have is an epidemic of Type II diabetes," said Dr. Lee Sanders, a spokesman for the American Diabetes Association (ADA).

Added Dr. Charles Billington, an endocrinologist and obesity expert at the Minneapolis Veterans Medical Center: "Type II diabetes should not be a disease of young people. That we are seeing it, and seeing it track with an explosion of obesity, tells us that there is something wrong."

When sugar isn't sweet

Part of the problem, experts say, is that most people are only vaguely aware of diabetes and the health problems it brings, which is why a diagnosis of the disease is typically followed by classes that focus on nutrition, medication management and self-care.

At the core of the classes, however, are such diabetes basics as what insulin is and the critical role it plays in the body.

According to Dr. David Kendall, medical director of Park Nicollet's International Diabetes Center in St. Louis Park, diabetes is a disorder of the body's metabolism -- the process by which we break down food and use it for energy. In people who have diabetes, the body either doesn't produce enough insulin, is resistant to it, or both.

Insulin, a hormone produced by the pancreas, essentially serves as a chemical escort for glucose, the sugar that results from the metabolizing of food. Glucose is the fuel of choice for the body's cells, but it needs to be accompanied by insulin to get into the cells.

In people with diabetes, something goes wrong with this process, Kendall said. Either there's not enough insulin to get glucose into the cells or the body resists the insulin's action. The result is that glucose builds up in the blood, eventually passing out of the body in urine.

An upset in the glucose balance can lead to serious effects, including nerve damage, infections and poor wound healing, kidney damage, blindness, amputations and an acceleration of cardiovascular disease. U.S. health care costs from diabetes are estimated at $98 billion a year by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

There are three main types of diabetes, according to the NIDDK. Perhaps creating some confusion about diabetes is that there have been different names for them, and they changed in recent years. Diabetes experts have settled on these:

  • Type I. This form of the disease used to be known as juvenile-onset diabetes, and also goes by the name of insulin-dependent diabetes mellitus (IDDM). It's considered a disease of the immune system because the body attacks cells in the pancreas that produce insulin. The result is that this organ produces little or no insulin.

  • Type II. Also known as adult-onset or non-insulin-dependent diabetes (NIDDM), Type II occurs when the body becomes resistant to insulin, doesn't produce enough, or both.

  • Gestational diabetes. As the name suggests, this condition occurs during pregnancy, when insulin levels or resistance fluctuate in some women. It usually disappears after they give birth, but women who develop it are at heightened risk of developing Type II later.

    Epidemic linked to obesity

    Each year, about 800,000 new cases of diabetes are diagnosed in the United States, with 90 to 95 percent of them being Type II. With that many people affected, Kendall said, it's easy to see why "the increasing incidence has caught people's attention."

    The risk of getting Type I diabetes is out of an individual's control. That's not so with Type II diabetes. Although many individuals inherit a higher risk, Sanders said, people's chances of developing it are much greater if they are obese and have the "common American lifestyle" that consists largely of sitting at a computer, watching a lot of television and driving instead of walking.

    Obesity affects the body's resistance to insulin, Kendall said. And because exercise -- or lack of it -- directly affects the likelihood of someone being overweight, a lack of exercise is correlated with the disease.

    Up to half of all Americans are considered overweight or obese, according to the National Institutes of Health, which is why many experts expect that the epidemic of Type II diabetes will continue. And "it's going to get worse before it gets better," Billington said.

    The good news is that Type II can often be prevented, delayed or managed by smart, healthful lifestyle choices, experts said. While Type I requires daily injections of insulin along with close attention to diet, the foundation of treatment for Type II is a low-fat diet and daily exercise.

    "It doesn't take a lot," Billington said. Often, even losing a small amount of weight -- around 10 pounds -- can have a significant effect on insulin resistance.

    A variety of options

    Tracking blood-glucose levels is another critical component of managing Type II or any other kind of diabetes, Kendall said. Doing so minimizes diabetes complications and helps physicians and patients monitor treatment effectiveness.

    People with Type II, however, may need to include other kinds of treatment in the management of their disease. The main types include:

  • Oral medications. Mainstays in diabetes treatment include a group of drugs called sulfonylureas (two common products are Glucotrol and DiaBeta). They stimulate the pancreas to produce more insulin, according to the Mayo Clinic Women's HealthSource.

    Metformin is another traditional workhorse of diabetes medications. It works by decreasing the amount of glucose produced by the body and enhances its ability to take up glucose.

    A new class of drugs called "glitazones" includes Avandia, Actos and Rezulin, a drug that recently was taken off the market for liver toxicity. Avandia and Actos appear to help the body use insulin more effectively, and, according to Kendall, may play a role in helping to reduce cardiovascular-disease risk, as well.

  • Insulin. Type II diabetics may need to augment the body's insulin supply by injecting this hormone. Needles, however, are fine-gauge, minimizing the discomfort of injections. In addition, new types of insulin (longer or shorter acting, as the situation requires) and new ways of delivering it (such as surgically implanted pumps) have become available to help people with diabetes manage their blood-glucose levels more efficiently.

    Physicians also are developing a type of insulin that can be administered by an inhaler. It's still experimental, but both Kendall and the ADA consider this type of insulin to be a promising new tool in diabetes management.

    Because the disease often has few symptoms or can go unnoticed for years, the ADA recommends annual screening (generally, a blood test after fasting) for people age 45 and older. Those at higher risk (such as those who are overweight, have a family history of diabetes or belong to ethnic groups that are at higher risk) should talk to their physicians about earlier screening.

    Although medicine has an increasing number of ways to detect and control diabetes, an ounce of prevention remains best, experts said. That includes a healthy diet, daily exercise and regular medical care.

    -- Jill Burcum writes about consumer health topics. She can be reached at jburcum@star

    tribune.com or at 425 Portland Av. S., Minneapolis, MN 55488.

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