"The Big Bang Theory"
The role: Sheldon, a genius who can handle calculus equations, but can't decipher how to talk to women.
Where you've seen him: As a would-be Klingon in 2004's "Garden State."
Why he's one to watch: His perfect comic delivery puts him aside Bill Gates and Stephen Hawking in the Nerd Hall of Fame.
In his own words: "This is definitely the biggest role I've had and the most exciting, too. It's nice to get to be active and not be sitting around waiting to do your two lines."
Behind the scenes: Co-star Johnny Galecki originally considered the Sheldon role, but opted for the part of the ever-so-slightly more adjusted Leonard.
The role: The devil. He uses a lowly department-store employee to round up escapees from down under, and we ain't talkin' Australia.
Where you've seen him: As Leland Palmer, a less-than-ideal citizen of "Twin Peaks."
Why he's one to watch: All this veteran actor has to do to scare up laughs is flash his pearly whites.
In his own words: "What would hell be for the devil? I guess it would be if there were no hell."
Behind the scenes: Kevin Smith, who once cast Alanis Morissette as God, directed the pilot.
"The Bionic Woman"