Minnetonka med-tech firm brings scanning into operating room

IMRIS is touting the cost savings of fewer follow-up surgeries to sell its surgical suites.

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Jay D. Miller says his company’s interoperative MRI scanners remove the lag time between finding and removing a tumor.

Photo: JOEL KOYAMA • jkoyama@startribune.com,

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Jay D. Miller looked down over the copper-sheathed surgical suites being built at IMRIS Inc.’s Minnetonka headquarters and dared to dream.

He dreams of a day when his company’s technology that allows surgeons to take detailed MRIs and CT scans of patients during surgery will be in many more hospitals worldwide. At a cost of $3.5 million to $7.5 million just to install the company’s interoperative MRI (iMRI) scanners, he understands it will take some time.

“It’s a significant capital expenditure,” said Miller, who has been at the helm of the company since July. “But high-volume neurosurgery hospitals, especially children’s hospitals touting pediatric oncology, are going to want our technology. If you can catch a brain tumor soon enough in a kid and completely remove it, the outlook is fantastic.”

That, in a nutshell, is what IMRIS and its 130-plus employees are selling — high-tech operating rooms featuring giant, ceiling mounted high resolution scanners that show images to the surgeon while the patient is on the operating table. Miller said that allows surgeons to go immediately back into a patient’s brain or spine for anything they missed without another operation.

Last month, the U.S. Food and Drug Administration approved IMRIS’ newest generation surgical suite — the Visius Surgical Theatre — that incorporates magnetic resonance imaging, CT and fluoroscopy into a connected set of rooms. The scanners move between the operating rooms on overhead tracks and have been used on more than the 13,000 patients.

Saving time, reducing risk

The company is also working to develop MRI-compatible surgical robots that will one day allow surgeons to operate while the MRI is actually being taken to make the procedure even more precise, Miller said.

“There will literally be no lag time between when the image is taken and when the surgeon removes the tumor,” he said.

The idea is to save time, save additional surgical procedures and improve patient safety and outcomes. Instead of a patient getting an MRI days before surgery, then another days later — only to discover that a bit of tumor remains — the IMRIS system means doctors can see what they missed and go back to work without the patient or surgeon leaving the operating room.

In 40 percent of cases involving IMRIS technology the surgeon discovered more work needed to be done after the initial surgery, Miller said. In 55 percent of tumor removal cases, the surgeon removed additional tumor after an interoperative MRI. And according to IMRIS, the technology allowed the surgeon to remove the total tumor in 86 percent of cases — vs. 55 percent without an iMRI.

Hospitals that have installed the technology include the Cleveland Clinic, Johns Hopkins in Baltimore, the Mayo Clinic in Jacksonville, Fla., and Duke Medical Center in Durham, N.C. Abbott Northwestern Hospital in Minneapolis and United Hospital in St. Paul were among the first U.S. health centers to install IMRIS’ technology, in 2007. Each hospital has performed close to 1,000 procedures using the IMRIS technology.

Helpful, but is it necessary?

“It’s wonderful,” said Dr. Mahmoud Nagib, a neurosurgeon who has done most of the cases performed at Abbott Northwestern. “At times, you have to do more than one scan, to make sure you get the complete tumor. I have done up to four scans during the surgery, before closing the exposure.”

He added: “The advantage is one anesthesia, not two anesthesias. You can identify if there is a complication. You know right away. With brain issues, time is of the essence.”

Last week, Nagib performed brain surgery on an 18-month-old baby and a 40-year-old adult, both using the IMRIS surgical suite. In other cases, he said, the IMRIS scanners caught hemorrhages that occurred during surgery and have spotted tumors or bits of tumor not seen in the first exposure.

“I believe in the value of this system,” he said. “Years ago, a doctor would say, ‘I think I got 99 percent of this tumor.’ But, days later, another scan would find more after the patient has been sewed up. Essentially, this saves the patient another operation.”

Dr. Eric S. Nussbaum, director of the neurovascular neurosurgery program at United Hospital, also has used the IMRIS technology seven or eight times in the past eight months. But while he said it’s a good and useful technology in some cases, it is not necessary for the majority of brain surgeries, including tumors.

There are cases where the expensive technology can be especially helpful, he said, such as with tumors that look a lot like normal brain tissue. It can also help in operations where scar tissue makes it difficult to differentiate tumors from healthy tissue. But in many cases, he said, “a good surgeon will know they have completely removed the tumor and should not be bleeding afterward.”

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  • IMRIS makes surgical suites that feature mobile MRI and CT scanners mounted overhead. The company also is working to develop a surgical robot (pictured) that doctors can use in the middle of the MRI machine, as the scans are being taken.

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