On the day he became the NFL's career leader in completed passes, Drew Brees' biggest plays came as a runner.

Brees' 1-yard run capped an 80-yard touchdown drive to open overtime that lifted the New Orleans Saints to a 43-37 victory over the host Atlanta Falcons on Sunday.

That came after his 7-yard score late in the fourth quarter forced the overtime. After the Saints won the coin toss, they held the ball for more than seven minutes.

Brees jumped over the pile on a quarterback keeper after his apparent 3-yard TD pass to Alvin Kamara was overturned. Brees scored on the next play, lifting the Saints (2-1) to their second consecutive victory.

"This was a wild one," said Brees, who passed for 396 yards and three touchdowns and ran for two scores. Kamara had 15 catches for 124 yards and ran for 66 yards.

Brees' biggest play before the winner might have been his improbable 7-yard scoring run with 1 minute, 15 seconds remaining that forced OT. He ran to his left and then spun to avoid tackle attempts by Brian Poole and Robert Alford.

"At some point, I felt they were coming to take my head off and I could probably spin out of it," Brees said.

With his 14th completed pass, the 39-year-old broke the record of 6,300 completions set by Brett Favre. Brees set the mark with a 17-yard pass to Michael Thomas in the second quarter.

Matt Ryan had his first career game with five scoring passes. Calvin Ridley became the first Falcons rookie with three scoring catches. That wasn't enough for Atlanta (1-2) vs. Brees and the high-scoring Saints, who gained 534 yards.

Seattle 24, Dallas 13: Russell Wilson threw for two touchdowns in the first half, Chris Carson added a 5-yard TD run early in the fourth quarter, and the host Seahawks (1-2) cruised past the Cowboys (1-2). Dallas quarterback Dak Prescott was sacked five times and the Cowboys had only 58 net yards passing entering the fourth quarter.

INTERCONFERENCE

Rams take battle of L.A., improve to 3-0

L.A. Rams 35, L.A. Chargers 23: Jared Goff passed for 354 yards and three TDs, and Todd Gurley rushed for 105 yards and another score, leading the host Rams over the Chargers in the franchises' first meeting since their relocations to Los Angeles.

"It felt like a good rivalry," said Goff, who was 29-for-36 in perhaps his most impressive pro performance.

Cory Littleton blocked a punt in the end zone and Blake Countess recovered it for an early touchdown for the Rams (3-0), who racked up 521 yards and remained one of the NFL's four unbeaten teams.

Philip Rivers passed for 226 yards and hit Mike Williams with two touchdown passes for the Chargers (1-2).

Kansas City 38, San Francisco 27: After winning his first three starts, all away from Arrowhead Stadium, second-year pro Patrick Mahomes finally made his regular-season home debut and torched the banged-up 49ers pass defense for 314 yards and three touchdowns, as the Chiefs improved to 3-0. Mahomes now has 13 touchdown passes without an interception, breaking Peyton Manning's NFL record for TD passes in the first three weeks of a season.

N.Y. Giants 27, Houston 22: Eli Manning threw for 297 yards and two touchdowns, rookie Saquon Barkley added a score and the Giants (1-2) dropped the host Texans to 0-3. Deshaun Watson threw for 385 yards and two scores for Houston, which trailed by 14 points at halftime.

Carolina 31, Cincinnati 21: Cam Newton threw for two touchdowns and ran for two others, while Christian McCaffrey racked up 184 yards rushing as the Panthers (2-1) won their seventh consecutive home game, beating the Bengals (2-1).

AFC

Mariota rallies Titans past Jaguars

Tennessee 9, Jacksonville 6: Marcus Mariota came off the bench and directed three scoring drives, including one in the fourth quarter, and the Titans (2-1) beat the host Jaguars (2-1) for the fifth time in six meetings. Mariota, who sat out last week after suffering an elbow injury in Week 1, replaced a concussed Blaine Gabbert in the first quarter. Mariota wore a glove on his injured right hand and was able to do just enough, completing 12 of 18 passes for 100 yards while running for 51 more.

Miami 28, Oakland 20: Receiver Albert Wilson threw a 52-yard touchdown pass to put the host Dolphins (3-0) ahead midway through the fourth quarter, and then turned a short reception into a 74-yard score that sealed it against the Raiders (0-3), who had a 17-minute advantage in time of possession.

Baltimore 27, Denver 14: Joe Flacco picked apart a depleted defense for 277 yards and a touchdown, and the host Ravens (2-1) beat the Broncos (2-1) on a rainy afternoon. The Ravens turned to their defense in the fourth quarter, twice stopping Denver drives inside their 15.